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CYM50260
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CYM50260图片
CAS NO:1355026-60-6
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
CYM50260 是一种有效且选择性强的鞘氨醇-1-磷酸 4 受体 (S1P4-R) 激动剂,EC50为 45 nM。CYM50260 对 S1P1-R,S1P2-R,S1P3-R 和 S1P5-R 无活性。
生物活性

CYM50260 is a potent and exquisitely selectivesphingosine-1-phosphate 4 receptor (S1P4-R)agonist with anEC50of 45 nM. CYM50260 displays no activity against S1P1-R, S1P2-R, S1P3-R and S1P5-R[1].

IC50& Target

EC50: 45 nM (S1P4-R)[1]

体外研究
(In Vitro)

CYM50260 (Compound 22aa) is a synthetic S1P4-R agonist. CYM50260 is found 3.5-fold more potent than the hit compound (HTS-hit)[1].
CYM50260 suppresses the collagen-stimulated platelet aggregation, PDGF-AB secretion and sCD40L release. CYM50260 reduces the release of phosphorylated-HSP27 by collagen as well as the phosphorylation of HSP27[2].

分子量

350.60

性状

Solid

Formula

C14H11Cl3FNO2

CAS 号

1355026-60-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
In solvent-80°C6 months
-20°C1 month