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FTY720(S)-Phosphate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
FTY720(S)-Phosphate图片
CAS NO:402616-26-6
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品名称
(S)-FTY720P
(S)-FTY720 phosphate
产品介绍
FTY720 (S)-Phosphate 是一种 S1P 受体 1 (S1PR1) 激动剂,可以用于急性肺损伤等急性炎症的研究。
生物活性

FTY720 (S)-Phosphate is an agonist ofS1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury.

IC50& Target

S1PR1[1]

体外研究
(In Vitro)

FTY720 (S)-Phosphate is an agonist of S1PR1. FTY720 (S)-Phosphate (Tys, 1 μM) maintains S1PR1 protein expression, enhances the human pulmonary artery endothelial cells barrier via S1PR1, but shows no effect on inducing ubiquitination of S1PR1. FTY720 (S)-Phosphate (0.01-50 μM) also reduces β-arrestin recruitment to S1PR1[1].

体内研究
(In Vivo)

FTY720 (S)-Phosphate (0.5 mg/kg, i.p.) preserves S1PR1 expression in mouse lungs, is protective in bleomycin-induced acute lung injury (ALI) and attenuates lung tissue leukocyte infiltration in bleomycin-injured mice[1].

分子量

387.45

性状

Solid

Formula

C19H34NO5P

CAS 号

402616-26-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years

*该产品在溶液状态不稳定,建议您现用现配,即刻使用。

溶解性数据
In Vitro: 

DMSO : 1 mg/mL(2.58 mM;ultrasonic and warming and heat to 80℃)

H2O :< 0.1 mg/mL(insoluble)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM2.5810 mL12.9049 mL25.8098 mL
5 mM---------
10 mM---------
*

请根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备液;该产品在溶液状态不稳定,建议您现用现配,即刻使用

In Vivo:
  • 1.

    FTY720 (S)-Phosphate is dissolved in sterile water[2].