| CAS NO: | 402616-26-6 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 生物活性 | FTY720 (S)-Phosphate is an agonist ofS1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury. | ||||||||||||||||
| IC50& Target | S1PR1[1] | ||||||||||||||||
| 体外研究 (In Vitro) | FTY720 (S)-Phosphate is an agonist of S1PR1. FTY720 (S)-Phosphate (Tys, 1 μM) maintains S1PR1 protein expression, enhances the human pulmonary artery endothelial cells barrier via S1PR1, but shows no effect on inducing ubiquitination of S1PR1. FTY720 (S)-Phosphate (0.01-50 μM) also reduces β-arrestin recruitment to S1PR1[1]. | ||||||||||||||||
| 体内研究 (In Vivo) | FTY720 (S)-Phosphate (0.5 mg/kg, i.p.) preserves S1PR1 expression in mouse lungs, is protective in bleomycin-induced acute lung injury (ALI) and attenuates lung tissue leukocyte infiltration in bleomycin-injured mice[1]. | ||||||||||||||||
| 分子量 | 387.45 | ||||||||||||||||
| 性状 | Solid | ||||||||||||||||
| Formula | C19H34NO5P | ||||||||||||||||
| CAS 号 | 402616-26-6 | ||||||||||||||||
| 运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
| 储存方式 |
*该产品在溶液状态不稳定，建议您现用现配，即刻使用。 | ||||||||||||||||
| 溶解性数据 | In Vitro: DMSO : 1 mg/mL(2.58 mM;ultrasonic and warming and heat to 80℃) H2O :< 0.1 mg/mL(insoluble) 配制储备液
* 请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。 In Vivo:
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