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KP496
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
KP496图片
CAS NO:217799-03-6
包装:5mg
市场价:26500元

产品介绍
KP49 是一个有选择性的Leukotriene D4andThromboxane A2受体的双重拮抗剂。
生物活性

KP496 is a selective, dual antagonist forLeukotriene D4 receptorandThromboxane A2 receptor.

IC50& Target

LTD4

 

TXA2Receptor

 

体内研究
(In Vivo)

KP496 significantly inhibits acute (day 7) and chronic (day 21) lung inflammation. KP496 attenuates the number of lymphocytes on day 7 and those of macrophages, neutrophils, and eosinophils on days 7 and 21. KP496 and prednisolone significantly suppress the increase of hydroxyl-L-proline content in the lung. Compare to respective vehicle control group, the inhibition ratio of KP496 and prednisolone for increase of hydroxyl-L-proline content is about 74 and 63%, respectively[1]. The KP496 (100 mg/head) group and prednisolone (10 mg/kg) group exhibit significant inhibition of numbers of infiltrating total cells, eosinophils, monocytes/macrophages, and lymphocytes compare with the control group. Infiltration of all types of cells except neutrophils is decreased in the KP496 (30m g/head) group, though not to significant extents[2].

分子量

692.27

性状

Solid

Formula

C31H34ClN3O7S3

CAS 号

217799-03-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month