CP-96021 hydrochloride is a balanced, combined, potent and orally activeleukotriene D4 (LTD4)/platelet activating factor (PAF)receptor antagonist withK_ivalues of 34 nM and 37 nM, respectively^[1].

In vivo, CP-96021 inhibits iv LTD4- and iv PAF-induced bronchoconstriction in guinea pigs withED₅₀s of 0.46 and 0.16 mg/kg p.o. respectively. CP-96021 effectively blocks the combined airway obstructive effects of endogenously released PAF and LTD4 stimulated by aerosolized antigen challenge in guinea pigs with anED₅₀s of 1.8 mg/kg p.o^[1].

529.03

C₂₉H₂₂ClFN₄OS

167011-22-5

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.