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AS-35
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AS-35图片
CAS NO:108427-72-1
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
AS-35 是一种有效的,可口服的,选择性的leukotrienes拮抗剂,抑制 LTC4,LTD4 和 LTE4 诱导的回肠收缩,IC50值分别为 8 nM,4 nM 和 3 nM,具有抗过敏的功效。
生物活性

AS-35 is an orally effective, potent and selective antagonist ofleukotrienes, antagonizes LTC4-, LTD4 and LTE4-induced contractions of the ileum withIC50values of 8 nM, 4 nM and 3 nM, respectively, and has antiallergic activities.

IC50& Target[1]

LTE4

3 nM (IC50, In isolated guinea pig ileum)

LTD4

4 nM (IC50, In isolated guinea pig ileum)

LTC4

8 nM (IC50, In isolated guinea pig ileum)

体外研究
(In Vitro)

In isolated guinea pig preparations, AS-35 antagonizes LTC4-, LTD4 and LTE4-induced contractions of the ileum with IC50values of 8 nM, 4 nM and 3 nM, respectively. In the trachea, the agent also antagonizes LTD4 and LTE4-induced con tractions with IC50values of 10 nM and 20 nM, respectively. However, AS-35 does not antagonize LTC4-induced tracheal contraction in the presence of L-serine borate[1].

体内研究
(In Vivo)

AS-35 (0.0375 to 0.3 mg/kg, i.v.) dose-dependently antagonizes bronchoconstriction induced by i.v.-injection of LTC4 and LTD4 in anesthetized guinea pigs, but does not inhibit histamine-induced bronchoconstriction. Oral administration of AS-35 also antagonizes LTD4 as well as antigen-induced LT-mediated bronchoconstriction. AS-35 (p.o.) inhibits LTD4-induced increase in the cutaneous vascular permeability of guinea pig[1].

分子量

420.42

Formula

C21H20N6O4

CAS 号

108427-72-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.