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(Rac)-BI 703704
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(Rac)-BI 703704图片
CAS NO:1423067-48-4
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
(Rac)-BI 703704 是有效的可溶性鸟苷酸环化酶(sGC)激活剂。(Rac)-BI 703704 减少 ZSF1 大鼠的肾脏损害进展,sGC 激活可作为糖尿病性肾病有效疗法的潜力.
生物活性

(Rac)-BI 703704 is a potentsoluble guanylyl cyclase (sGC)activator. (Rac)-BI 703704 reduces progression of renal damage in the ZSF1 rat, and highlight the potential of sGC activation as an effective therapy for diabetic nephropathy[1].

体内研究
(In Vivo)

(Rac)-BI 703704 (0.3-10 mg/kg; food intake; daily for 15 weeks) inhibits the progression of diabetic nephropathy in the ZSF1 rat[1].

Animal Model:12-13 weeks male ZSF1 obese rats[1]
Dosage:0.3, 1, 3, or 10 mg/kg
Administration:Food intake; daily for 15 weeks
Result:Dose-dependent increased in renal cGMP levels; Dosedependent decreased in urinary protein excretion (UPE); Accompanied by a significant reduction in the incidence of glomerulosclerosis and interstitial lesions.
分子量

559.72

Formula

C32H37N3O4S

CAS 号

1423067-48-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.