[Des-His1,Glu9] Glucagon

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

110121-11-4

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

[Des-His1,Glu9] Glucagon是一种有效的胰高血糖素受体系统多肽拮抗剂。[Des-His1,Glu9] Glucagon 增强胰岛细胞在葡萄糖刺激下释放胰岛素。[Des-His1,Glu9] Glucagon 可用于糖尿病的研究。

生物活性

[Des-His1,Glu9] Glucagon is a potentglucagon receptorsystempeptide antagonist. [Des-His1,Glu9] Glucagon enhances the glucose-stimulated release ofinsulinfrom pancreatic islet cells. [Des-His1,Glu9] Glucagon can be used to research diabetes^[1].

IC₅₀& Target

Glucagon Receptor^[1]

体外研究
(In Vitro)

[Des-His1,Glu9] Glucagon (1 pM-100 μM) does not activate membrane-bound adenylate cyclase up to a concentration of 2×10^-4molar in the cAMP assay on isolated rat liver membranes (from male Sprague Dawley rats)^[1].

体内研究
(In Vivo)

[Des-His1,Glu9] Glucagon (3.6-4.0 μg/kg for rabbits, 1 mg/kg for rats; i.v.; single dosage) suppresses hyperglycemic effects in rabbits and rats^[1].

Animal Model:	New Zealand rabbits (2.8-3.8 kg; fasted for 18 hours)^[1]
Dosage:	3.6-4.0 μg/kg
Administration:	i.v.; single dosage
Result:	Suppressed hyperglycemic response of glucagon.

Animal Model:	Male Wistar rats weighing [350-400 mg; hyperglycemia induced by i.p. injection of 65 mg/kgStreptozotocin(HY-13753)]^[1]
Dosage:	1 mg/kg
Administration:	Intravenously administration through the tail vein; single dosage
Result:	Decreased blood glucose rapidly, and reduced hyperglycemic effect by 70% within 5 min.

分子量

3359.63

Formula

C₁₄₈H₂₂₀N₄₀O₄₈S

CAS 号

110121-11-4

Sequence Shortening

SQGTFTSEYSKYLDSRRAQDFVQWLMNT

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.