| CAS NO: | 34262-64-1 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| Cas No. | 34262-64-1 |
| 别名 | 8,11,14-ETI |
| 化学名 | 8,11,14-eicosatriynoic acid |
| Canonical SMILES | CCCCCC#CCC#CCC#CCCCCCCC(O)=O |
| 分子式 | C20H28O2 |
| 分子量 | 300.4 |
| 溶解度 | ≤100mg/ml in ethanol;100mg/ml in DMSO;100mg/ml in dimethyl formamide |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | 8,11,14-Eicosatriynoic Acid, as an inhibitor of prostaglandin, leukotriene biosynthesis, and arachidonic acid induced platelet aggregation, blocks human 12-lipoxygenase (12-LO), cyclooxygenase (COX), and 5-lipoxygenase (5-LO) with IC50 values of 0.46 μM, 14 μM, and 25 μM, respectively. Also, it inhibits the actions of slow-reacting substance of anaphylaxis with an IC50 value of 10 μM [1,2]. Lipoxygenases are found widely in fungi, plants, and animals in high levels. 12-LO is involved in a number of significant disease states and may play a role in oxidative glutamate toxicity. COX enzymes play elaborate roles in human physiology and pathology, involving neuronal, immune, renal, cardiovascular, gastrointestinal, and reproductive systems. COX enzymes are blocked by aspirin and a wide variety of other non-steroidal anti-inflammatory drugs, which makes them important clinically [3]. 5-LO is involved in cancer pathobiology. It is expressed by a variety of cancer cells including colon, lung, breast, and prostate and promotes cancer cell growth and neo-angiogenesis. In vitro: Up to now, in vitro study of 8,11,14-Eicosatriynoic Acid is still in the development stage. In vivo: Up to now, in vivo study of 8,11,14-Eicosatriynoic Acid is still in the development stage. References: |
m.cnreagent.com