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GLP-2(1-33)(human)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:223460-79-5
包装与价格:
包装价格(元)
500 μg电议
1mg电议
5mg电议
10mg电议
50mg电议

产品名称
GLP-2 (human)
Glucagon-like peptide 2 (human)
产品介绍
GLP-2(1-33) (human) 是一种肠内分泌激素可以与GLP-2受体结合并且刺激肠上皮细胞生长。
生物活性

GLP-2(1-33) (human) is an enteroendocrine hormone which can bind to theGLP-2 receptorand stimulate the growth of intestinal epithelium.

IC50& Target

GLP-2 receptor[1]

体外研究
(In Vitro)

GLP-2-treated group demonstrates a 518±22% increase (P<0.05) in mucosal IGFBP-4 mRNA levels as compare with vehicle-treated controls. Because the mucosal expression of IGFBP-4 transcripts is found to be very low relative to that of the whole intestine, FRIC cultures are used as anin vitromodel of the entire intestine. FRIC cultures have previously been established to express a functional GLP-2 receptor (GLP-2R) that displays a cAMP response, as well as enhances IGF-1 mRNA expression and IGF-1 secretion in response to GLP-2 treatment. When incubates with GLP-2 (10–8M) for 2 hours, IGFBP-4 mRNA expression in the FRIC cultures is also found to be increased, by 40.8±15.2% (P<0.05), compare with vehicle-treated cells[1].

体内研究
(In Vivo)

GLP-2 quickly increases apoB48 mass in the TRL fraction of plasma, which is indicative of chylomicron number, and this is blocked by L-NAME. GLP-2 treatment alone increases postprandial TRL-lipids (slope 3.65±0.73×10–3g/L/min vs 1.63±0.28×10–3g/L/min, GLP-2 vs control), and this effect is completely mitigated by L-NAME pretreatment (slope 3.67±0.15×10–4g/L/min). The GLP-2-induced rise in TRL-apoB48 occurres within 30 minutes and precedes the rise in TRL-TG. GLP-2 acutely increases plasma tritium levels (slope, 1.66±0.25×102dpm/mL/min vs 1.11±0.17×102dpm/mL/min, GLP-2 vs control)[2].

分子量

3766.19

性状

Solid

Formula

C165H254N44O55S

CAS 号

223460-79-5

Sequence

His-Ala-Asp-Gly-Ser-Phe-Ser-Asp-Glu-Met-Asn-Thr-Ile-Leu-Asp-Asn-Leu-Ala-Ala-Arg-Asp-Phe-Ile-Asn-Trp-Leu-Ile-Gln-Thr-Lys-Ile-Thr-Asp

Sequence Shortening

HADGSFSDEMNTILDNLAARDFINWLIQTKITD

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light

Powder-80°C2 years
-20°C1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
In Vitro: 

H2O : 25 mg/mL(6.64 mM;ultrasonic and adjust pH to 9 with NH4OH)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM0.2655 mL1.3276 mL2.6552 mL
5 mM0.0531 mL0.2655 mL0.5310 mL
10 mM---------
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture and light)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。