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SKF 38393 hydrobromide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SKF 38393 hydrobromide图片
CAS NO:20012-10-6
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
(±)-SKF-38393 hydrobromide
产品介绍
SKF 38393 ((±)-SKF-38393) hydrobromide 是一种 多巴胺 D1 受体 (dopamine D1 receptor) 的选择性激动剂,IC50值为 110 nM。
生物活性

SKF 38393 ((±)-SKF-38393) hydrobromide is a selective agonist of thedopamine D1 receptor (D1DR)with anIC50of 110 nM[1].

IC50& Target[1]

D1Receptor

110 nM (IC50)

体外研究
(In Vitro)

SKF 38393 hydrobromide induces a similar change in cytomorphology and increases the levels of media cAMP[2].
SKF-38393 hydrochloride (10 μM; 1 hour) induces increased threonine-phosphorylation of DA- and cAMP-regulated phosphoprotein of Mr 32 kD (DARPP-32) in cultured GC cells[2].

Western Blot Analysis[2]

Cell Line:GC cells
Concentration:10 μM
Incubation Time:1 hour
Result:Induced increased threonine-phosphorylation of DARPP-32 in cultured GC cells.
体内研究
(In Vivo)

SKF 38393 hydrobromide (10 mg/kg; i.p.) blocks the 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) -induced depletion of glutathione[3].
SKF 38393 hydrobromide attenuates MPTP-induced depletion of dopamine[3].
SKF 38393 hydrobromide enhances the activity of superoxide dismutase and hence mimics the action of Selegiline[3].
SKF 38393 hydrobromide enhances the frequency but not the amplitude of tetrodotoxin-resistant excitatory postsynaptic currents which argues for a presynaptic locus of D1 action[4].

Animal Model:Balb/c mice (20-25 g)[3]
Dosage:5 mg/kg, 10 mg/kg
Administration:Intraperitoneal injection
Result:Blocked the MPTP-induced depletion of glutathione and attenuated MPTP-induced depletion of dopamine.
分子量

336.22

Formula

C16H18BrNO2

CAS 号

20012-10-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.