MIF-1 (Melanostatin), an endogenous brain peptide, is a potentdopamine receptorallosteric modulator. MIF-1 inhibits melanin formation. MIF-1 blocks the effects ofopioid receptoractivation to modulate the analgesic effects of morphine and stress-induced analgesia (SIA). MIF-1 accesses from the blood to the CNS by directly crossing the blood-brain barrier (BBB)^[1][2][3].

MIF-1 (Melanostatin, 1 μM) provokes a reversible hyperpolarization and a suppression of spontaneous action potentials^[2].

MIF-1 (Melanostatin, 1 mg/kg; i.p.; once, for 1 hour; male Wistar rats) modulates the analgesic effects of morphine and stress-induced analgesia (SIA)^[1].
MIF-1 (Melanostatin, 1 mg/kg; i.p.; daily, for 8 weeks; Sprague-Dawley rats) attenuates spiroperidol-induced impairment of development of striatal dopamine D2 receptors in rats^[3].

284.35

C₁₃H₂₄N₄O₃

2002-44-0

Room temperature in continental US; may vary elsewhere.

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