SD-36 is a novel, potent and highly efficacious STAT3 degrader based on PROTAC technology with a Kd of ~50 nM, demonstrating high selectivity over other STAT family members and in vivo antitumor activity. SD-36 also effectively degrades mutated STAT3 proteins in cells and suppresses the transcriptional activity of STAT3 (IC50=10 nM). SD-36 exerts robust anti-tumor activity, and achieves complete and long-lasting tumor regression in mouse tumor models. SD-36 is composed of the STAT3 inhibitor SI-109, a linker, and an analog of CRBN ligand Lenalidomide for E3 ubiquitin ligase.

纯度：≥98%

CAS：2429877-44-9