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SD-36
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SD-36图片
CAS NO:2429877-44-9
规格:≥98%
包装与价格:
包装价格(元)
2mg电议
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍

SD-36 is a novel, potent and highly efficacious STAT3 degrader based on PROTAC technology with a Kd of ~50 nM, demonstrating high selectivity over other STAT family members and in vivo antitumor activity. SD-36 also effectively degrades mutated STAT3 proteins in cells and suppresses the transcriptional activity of STAT3 (IC50=10 nM). SD-36 exerts robust anti-tumor activity, and achieves complete and long-lasting tumor regression in mouse tumor models. SD-36 is composed of the STAT3 inhibitor SI-109, a linker, and an analog of CRBN ligand Lenalidomide for E3 ubiquitin ligase.

纯度:≥98%

CAS:2429877-44-9