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CGS 21680
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CGS 21680图片
CAS NO:120225-54-9
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
CGS 21680 是一种选择性的adenosine A2A receptor特异性激动剂,Ki值为 27 nM。
生物活性

CGS 21680 is a selectiveadenosine A2A receptoragonist, with aKiof 27 nM.

IC50& Target

Ki: 27 nM (Adenosine A2A receptor)[5]

体外研究
(In Vitro)

CGS21680 significantly upregulates CD39 and CD73 expression. CGS21680 accelerates the adenosine triphosphate (ATP) hydrolysis and adenosine generation[1]. CGS21680 (10 nM) alone shows only small survival activity, but the activity is significantly enhanced by the addition of a phosphodiesterase inhibitor, IBMX. The survival activity of CGS21680 on cultured motoneurons is exerted by mixed effects of the adenylate cyclase-cAMP-PKA pathway and the transactivation of neurotrophin receptors[4].

体内研究
(In Vivo)

CGS21680 (1 mg/kg/i.p.) intervention promotes the development of EAN. CGS21680 exacerbates experimental autoimmune neuritis in Lewis rats induced with bovine peripheral myelin. The exacerbation is accompanied with reduced CD4+Foxp3+T cells, increased CD4+CXCR5+T cells, B cells, dendritic cells and antigen-specific autoantibodies, which is possibly due to the inhibition of IL-2 induced by CGS21680[2]. CGS21680 (0.1 mg/kg, i.p.) transiently increases heart frequency but does not modify blood pressure of rat, and does not modify either heart frequency or blood pressure at 0.01 mg/kg. Following transient MCAo, CGS21680 at both doses protects from neurological deficit from the first day up to 7 days thereafter. At this time, it has reduced microgliosis, astrogliosis and improved myelin organization in the striatum and cytoarchitecture of the ischemic cortex and striatum. Two days after transient MCAo, CGS21680 has reduced the number of infiltrated granulocytes into the ischemic tissue[3].

分子量

499.52

Formula

C23H29N7O6

CAS 号

120225-54-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.