CAS NO: | 96760-69-9 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | Adenosine amine congener (ADAC) is a selectiveA1adenosine receptoragonist, can ameliorate noise- and Cisplatin-induced cochlear injury. Adenosine amine congener also has neuroprotective effects[1][2]. | ||||||||||||||||
IC50& Target | A1 adenosine receptor[1][2] | ||||||||||||||||
体外研究 (In Vitro) | Adenosine amine congener can reduce oxidative stress in the noise-exposed cochlea, leading to protection of sensory hair cells. Adenosine amine congener also can reduce cisplatin-induced apoptosis in cochlear tissues, particularly in sensory hair cells and strial marginal cells. The mechanisms of otoprotection by Adenosine amine congener include inhibition of glutamate release via presynaptic A1 receptors and inhibition of voltage-gated Ca2+channels, which can prevent activation of apoptotic and necrotic cell death pathways[1]. | ||||||||||||||||
体内研究 (In Vivo) | Adenosine amine congener (25-300 μg/kg/day; intraperitoneal injection; daily; for 5 days; male Wistar rats) treatment is most effective in the first 24 hours after noise exposure at doses >50 μg/kg, providing up to 21 dB protection. Adenosine amine congener mitigates noise-induced hearing loss in a dose- and time-dependent manner[1].
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分子量 | 576.60 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C28H32N8O6 | ||||||||||||||||
CAS 号 | 96760-69-9 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 31.25 mg/mL(54.20 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
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