CAS NO: | 83-67-0 |
包装 | 价格(元) |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | Theobromine is a methylxanthine found in cacao beans which can inhibitadenosine receptorA1(AR1) signaling. | ||||||||||||||||
IC50& Target | AR1[1] | ||||||||||||||||
体外研究 (In Vitro) | Theobromine, at concentrations above 25 μM, decreases lipid accumulation in these cells. Cell viability is not affected by Theobromine. Theobromine, at concentrations above 25 μM, suppresses protein expression of PPARγ, C/EBPα and adipogenic genes. The mRNA levels of these genes are also decreased by Theobromine[1]. | ||||||||||||||||
体内研究 (In Vivo) | Body weights are lower in the Theobromine group than in the vehicle group. In addition, Theobromine suppresses gains in weight of epididymal and perirenal adipose tissues. The mean adipocyte area is smaller in the Theobromine group than in the vehicle group[1]. Theobromine group shows lower counts than the other groups when considering the number of bacteria per fecal weight (p=0.021 and p=0.055 compare to the reference (RF) and the cocoa (CC) groups, respectively). The Theobromine diet leads to higher pH values than those found after the RF and CC diets. Fecal concentrations of lactic acid are not significantly affected by the experimental diets (4.26±1.54 mM in RF group; 1.96±0.41 mM in CC group; 2.69±0.73 mM in Theobromine group)[2]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 180.16 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C7H8N4O2 | ||||||||||||||||
CAS 号 | 83-67-0 | ||||||||||||||||
结构分类 |
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来源 |
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运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 1.1 mg/mL(6.11 mM;Need ultrasonic) H2O : 1.1 mg/mL(6.11 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |