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Theobromine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Theobromine图片
CAS NO:83-67-0
包装与价格:
包装价格(元)
100mg电议
200mg电议
500mg电议

产品名称
可可碱
3,7-Dimethylxanthine
产品介绍
Theobromine 是在可可豆中发现的甲基黄嘌呤,可以抑制腺苷受体 A1 (AR1) 信号传导。
生物活性

Theobromine is a methylxanthine found in cacao beans which can inhibitadenosine receptorA1(AR1) signaling.

IC50& Target

AR1[1]

体外研究
(In Vitro)

Theobromine, at concentrations above 25 μM, decreases lipid accumulation in these cells. Cell viability is not affected by Theobromine. Theobromine, at concentrations above 25 μM, suppresses protein expression of PPARγ, C/EBPα and adipogenic genes. The mRNA levels of these genes are also decreased by Theobromine[1].

体内研究
(In Vivo)

Body weights are lower in the Theobromine group than in the vehicle group. In addition, Theobromine suppresses gains in weight of epididymal and perirenal adipose tissues. The mean adipocyte area is smaller in the Theobromine group than in the vehicle group[1]. Theobromine group shows lower counts than the other groups when considering the number of bacteria per fecal weight (p=0.021 and p=0.055 compare to the reference (RF) and the cocoa (CC) groups, respectively). The Theobromine diet leads to higher pH values than those found after the RF and CC diets. Fecal concentrations of lactic acid are not significantly affected by the experimental diets (4.26±1.54 mM in RF group; 1.96±0.41 mM in CC group; 2.69±0.73 mM in Theobromine group)[2].

Clinical Trial
分子量

180.16

性状

Solid

Formula

C7H8N4O2

CAS 号

83-67-0

结构分类
  • Alkaloids
  • Other Alkaloids
来源
  • Plants
  • Sterculiaceae
  • Cocoa beans
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

DMSO : 1.1 mg/mL(6.11 mM;Need ultrasonic)

H2O : 1.1 mg/mL(6.11 mM;Need ultrasonic)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM5.5506 mL27.7531 mL55.5062 mL
5 mM1.1101 mL5.5506 mL11.1012 mL
10 mM---------
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。