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Topoisomerase II inhibitor 4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Topoisomerase II inhibitor 4图片
CAS NO:2560590-49-8
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Topoisomerase II inhibitor 4 (compound E17) 是一种有效的拓扑异构酶 II (Topoisomerase II) 抑制剂。Topoisomerase II inhibitor 4 具有抗肿瘤作用,引起 G2/M 期细胞周期阻滞,抑制癌细胞增殖并显示出细胞毒性。
生物活性

TopoisomeraseII inhibitor 4 (compound E17) is a potentTopoisomeraseIIinhibitor.TopoisomeraseII inhibitor 4 triggers G2/M cell cycle arrest and shows anti-tumor activity with strong cytotoxic and anti-proliferative effect[1].

IC50& Target

Topoisomerase II

 

体外研究
(In Vitro)

Topoisomerase II inhibitor 4 (compound E17) inhibits cancer cells with IC50values of 4.55 μM (MDA-MB-231), 6.61 μM (A549), 2.18 μM (KG1)[1].
Topoisomerase II inhibitor 4 (1 μM; 0-22 h) induces G2/M cell cycle arrest[2].
Topoisomerase II inhibitor 4 (5 μM; 4 h) inhibits topo II-mediated chromosomes condensation in CRC cells, while also (100 μM; 0.5, 1, 2 h) induces topo II–DNA complex accumulation without degradation of topo II[2].
Topoisomerase II inhibitor 4 (1 μM; 4 h) exerts anti-tumor activity without increasing gH2AX levels in HCT116, while no DNA damage and apoptosis as well[2].

Cell Migration Assay[2]

Cell Line:HCT116, and WI-38 cells
Concentration:0.4, 0.6, 0.8, 1.0, 1.2 μM
Incubation Time:0, 12, 24, 48 hours
Result:Resulted migration inhibition in HCT116 and SW480 cells.

Cell Viability Assay[2]

Cell Line:HCT116, and WI-38 cells
Concentration:0.39, 0.78, 1.56, 3.12, 6.25, 12.5, 25 μM
Incubation Time:72 hours
Result:Exerted anti-proliferative effect in a dose-dependent manner.
分子量

459.50

Formula

C25H25N5O4

CAS 号

2560590-49-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.