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Urotensin II(human)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Urotensin II(human)图片
CAS NO:251293-28-4
包装:1mg
市场价:2716元

产品介绍
Potent endogenous peptide agonist for the urotensin-II receptor
Cas No.251293-28-4
化学名(S,Z)-5-(((2S,3R)-1-((S)-2-((Z)-(((S,Z)-1-(((4R,5Z,7S,8Z,10S,11Z,13S,14Z,16S,17Z,19R)-13-((1H-indol-3-yl)methyl)-10-(4-aminobutyl)-16-benzyl-4-((Z)-(((S)-1-carboxy-2-methylpropyl)imino)(hydroxy)methyl)-6,9,12,15,18-pentahydroxy-7-(4-hydroxybenzyl)-1,2-dit
Canonical SMILESCC([C@@](/N=C(O)/[C@]1([H])CSSC[C@@](/N=C(O)/[C@](/N=C(O)/[C@]2([H])CCCN2C([C@](/N=C(O)/[C@](N)([H])CCC(O)=O)([H])[C@@](O)([H])C)=O)([H])CC(O)=O)([H])/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/1)([H])CC3=CC=C(O)C=C3)([H])CCCCN)([H])CC
分子式C64H85N13O18S2
分子量1388.57
溶解度Soluble in 20% acetonitrile / sterile Water
储存条件Desiccate at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Urotensin II (114-124), human, an 11-amino acid residue peptide, is a potent vasoconstrictor and agonist for the orphan receptor GPR14.

Human Urotensin II (U-II) binds to recombinant human GPR14 with high affinity, and the binding is functionally coupled to calcium mobilization. Human Urotensin II induces concentration-dependent increases in intracellular calcium in a HEK-293 cell line expressing human GPR14 (EC50=0:62±0.17 nM, n=6)[1].

Human Urotensin II (U-II) markedly increases total peripheral resistance in anaesthetized non-human primates, a response associated with profound cardiac contractile dysfunction[1].

References:
[1]. Ames RS, et al. Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14. Nature. 1999 Sep 16;401(6750):282-6.