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Razoxane
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Razoxane图片
CAS NO:21416-67-1
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
ICRF 159
产品介绍
Razoxane (ICRF 159) 是一种抗血管生成拓扑异构酶 II (topoisomerase II) 抑制剂,可用于肾细胞癌 (RCC) 的研究。
生物活性

Razoxane (ICRF 159) is an antiangiogenictopoisomeraseIIinhibitor, can be used for the research of renal cell carcinoma (RCC)[1].

IC50& Target[1]

Topoisomerase II

 

体外研究
(In Vitro)

Razoxane (30 mg/kg; i.p.) exhibits antimetastatic effects in a rat osteosarcoma model.

体内研究
(In Vivo)

Early treatment with Razoxane (30 mg/kg i.p. from day -2 to +14) shows a greater inhibition of pulmonary metastases than later treatment (30 mg/kg i.p. from day +14 to +28 after transplantation)[2].

Animal Model:Sprague-Dawley rats[2]
Dosage:30 mg/kg or 10 mg/kg per day
Administration:Intraperitoneally (i.p.) from 2 days before to 14 days after tumor transplantation
Result:Resulted in a dose-dependent prolongation of median survival time (83 or 48 days respectively, versus 38 days for the control group), but showed no influence on the growth of the primary tumor.
分子量

268.27

Formula

C11H16N4O4

CAS 号

21416-67-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.