CAS NO: | 174402-32-5 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | Edotecarin is a potent inhibitor oftopoisomeraseIthat can induces single-strand DNA cleavage, withIC50of 50 nM. | ||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | In the presence of human colon cancer cells labeled with3Hthymidine, edotecarin (0.6 μmol/L) increases the formation of DNA-protein complexes in a time-dependent manner[1]. | ||||||||||||
体内研究 (In Vivo) | Edotecarin produces an 83% increase in survival in mice bearing intracranial D-456MG glioma and shows a strong antimetastatic effect[1]. Edotecarin results in tumor growth delays ranging from 10.45 days at the lowest dose (3 mg/kg) to 24.83 days at the highest (100 mg/kg). Combination treatment of edotecarin plus irinotecan improves antitumor activity in vivo compared with either agent alone[2]. | ||||||||||||
Clinical Trial | |||||||||||||
分子量 | 608.55 | ||||||||||||
性状 | Solid | ||||||||||||
Formula | C29H28N4O11 | ||||||||||||
CAS 号 | 174402-32-5 | ||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||
储存方式 |
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