您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > Edotecarin
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Edotecarin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Edotecarin图片
CAS NO:174402-32-5
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
J 107088
PF 804950
产品介绍
Edotecarin 是一种有效的topoisomerase I抑制剂,可诱导单链 DNA 断裂,IC50值为 50 nM。
生物活性

Edotecarin is a potent inhibitor oftopoisomeraseIthat can induces single-strand DNA cleavage, withIC50of 50 nM.

IC50& Target[1]

Topoisomerase I

50 nM (IC50)

Protein Kinase C

160 μM (IC50)

体外研究
(In Vitro)

In the presence of human colon cancer cells labeled with3Hthymidine, edotecarin (0.6 μmol/L) increases the formation of DNA-protein complexes in a time-dependent manner[1].

体内研究
(In Vivo)

Edotecarin produces an 83% increase in survival in mice bearing intracranial D-456MG glioma and shows a strong antimetastatic effect[1]. Edotecarin results in tumor growth delays ranging from 10.45 days at the lowest dose (3 mg/kg) to 24.83 days at the highest (100 mg/kg). Combination treatment of edotecarin plus irinotecan improves antitumor activity in vivo compared with either agent alone[2].

Clinical Trial
分子量

608.55

性状

Solid

Formula

C29H28N4O11

CAS 号

174402-32-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month