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Ellipticine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ellipticine图片
CAS NO:519-23-3
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品名称
NSC 71795
产品介绍
Ellipticine (NSC 71795) 是一种有效的抗肿瘤剂; 抑制DNA拓扑异构酶II活性。
生物活性

Ellipticine (NSC 71795) is a potent antineoplastic agent; inhibitsDNAtopoisomeraseIIactivities.

IC50& Target[1]

Topoisomerase II

 

体外研究
(In Vitro)

Ellipticine (NSC 71795) is a potent antineoplastic agent exhibiting the multimodal mechanism of its action. The mechanisms of Ellipticine (NSC 71795) antitumor, mutagenic and cytotoxic activities are suggested to be intercalation into DNA and inhibition of DNA topoisomerase II activity. Another mode of Ellipticine (NSC 71795) action is the formation of covalent DNA adducts mediated by its oxidation with cytochromes P450 (CYP) and peroxidases[1]. Ellipticine (NSC 71795) can also act as an inhibitor or inducer of biotransformation enzymes, thereby modulating its own metabolism leading to its genotoxic and pharmacological effects. Treatment of cells with Ellipticine (NSC 71795) results in inhibition of cell growth and proliferation. This effect is associated with formation of two covalent Ellipticine (NSC 71795)-derived DNA adducts[2].

体内研究
(In Vivo)

Ellipticine (NSC 71795) treatment results in Ellipticine (NSC 71795)-derived DNA adduct generation in several healthy organs (liver, kidney, lung, spleen, breast, heart and brain) and in DNA of mammary adenocarcinoma. The levels of Ellipticine (NSC 71795)-derived DNA adducts generated in these adenocarcinomas are almost 2-fold higher than in normal healthy mammary tissue. The induced expression of cytochrome b5protein in liver of rats treated with Ellipticine (NSC 71795) suggests that cytochrome b5may modulate the CYP-mediated bioactivation and detoxification of Ellipticine (NSC 71795)[3].

分子量

246.31

Formula

C17H14N2

CAS 号

519-23-3

中文名称

玫瑰树碱;椭圆玫瑰树碱

结构分类
  • Alkaloids
  • Indole Alkaloids
来源
  • Plants
  • Apocynaceae
  • Amsonia elliptica (Thunberg ex Murray) Roemer & Schultes
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

溶解性数据
In Vitro: 

DMSO : 5.8 mg/mL(23.55 mM;Need ultrasonic and warming)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM4.0599 mL20.2996 mL40.5992 mL
5 mM0.8120 mL4.0599 mL8.1198 mL
10 mM0.4060 mL2.0300 mL4.0599 mL