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Indomethacin(Indometacin)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Indomethacin(Indometacin)图片
CAS NO:53-86-1
规格:≥98%
包装与价格:
包装价格(元)
1g电议
2g电议
5g电议
10g电议
25g电议
50g电议
100g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)357.79
FormulaC19H16ClNO4
CAS No.53-86-1
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 72 mg/mL (201.2 mM)
Water: <1 mg/mL
Ethanol: 24 mg/mL (67.1 mM)
Other info

Chemical Name: 2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetic acid

InChi Key: CGIGDMFJXJATDK-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)

SMILES Code: O=C(O)CC1=C(C)N(C(C2=CC=C(Cl)C=C2)=O)C3=C1C=C(OC)C=C3

SynonymsIndometacin; Indocin.
实验参考方法
In Vitro

In vitro activity: Indomethacin inhibits transcription of a beta-catenin/TCF-responsive reporter gene in a dose dependent manner. Indomethacin also downregulates the beta-catenin/TCF transcriptional target cyclin D1. Indomethacin attenuates the transcription of beta-catenin/TCF-responsive genes, by modulating TCF activity without disrupting beta-catenin/TCF complex formation.

In VivoIndomethacin increases BrdU+ cells of all lineages and reduces microglial/monocyte activation in rats after focal cerebral ischemia. Indomethacin (7.5 mg/kg, one injection) produces acute injury and inflammation in the distal jejunum and proximal ileum that are maximal at three days and completely resolves within one week. Indomethacin (two daily subcutaneous injections) produces a more extensive and chronic inflammation that lasts in an active form in more than 75% of the rats for at least two weeks. Indomethacin (4ppm) reduces tumor yield by 78% in SKH:HR-1-hrBr hairless mice. Indomethacin (20 mg/kg, orally) increases the total area of gastric erosions and concentration of lipid peroxides in the gastric mucosa of rats. Indomethacin increases the alpha-tocopherol:total cholesterol ratio in serum. Indomethacin inhibits the increases in gastric mucosal erosions and lipid peroxides in the gastric mucosa, and the reduction of serum alpha-tocopherol.
Animal modelRats
Formulation & Dosage7.5 mg/kg, injection; 20 mg/kg, oral
References

Oncogene. 2001 Feb 1;20(5):645-53; Stroke. 2005 Dec;36(12):2718-24; Inflammation. 1993 Dec;17(6):641-62.