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Neuromedin U(rat)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Neuromedin U(rat)图片
CAS NO:117505-80-3
包装:1mg
市场价:1701元

产品介绍
Neuromedin U(大鼠)是一种 23 个氨基酸的脑肠肽。
Cas No.117505-80-3
别名Neuromedin U (rat); Rat neuromedin U-23
化学名(2S,3Z,5S,6Z,8S,9Z,11S,12Z,14S)-2-amino-14-((Z)-(((S,Z)-1-(((S,Z)-1-((2-((S)-2-((Z)-(((S,Z)-1-(((S)-1-((S)-2-((1Z,3S,4Z,7Z,10Z,12S,13Z,15S,16Z,18S,19Z,21S,22Z,24S)-29-amino-12,15,21-tribenzyl-24-((S)-2-((Z)-(((S,Z)-1-(((S)-1,4-dihydroxy-1,4-diiminobutan-2
Canonical SMILESCC(C[C@@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/C/N=C(O)/C/N=C(O)/[C@](/N=C(O)/[C@]1([H])CCCN1C([C@](/N=C(O)/[C@](/N=C(O)/[C@]2([H])CCCN2C(C/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](N)([H])CC3=CC=C(O)C=C3)([H])
分子式C124H180N34O31
分子量2642.97
溶解度Soluble to 1 mg/ml in Water
储存条件Desiccate at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Neuromedin U, rat is a 23-amino acid brain-gut peptide. Neuromedin U (NMU), through its cognate receptor NMUR2 in the central nervous system, regulates several important physiological functions, including energy balance, stress response, and nociception.

To establish an electrochemiluminescent (ECL) binding assay for NMUR2 receptor, the peptide Neuromedin U (NMU-23) is labeled at the N terminus with Ru(bpy)2+3 and allowed to bind to the human NMUR2 receptor in the cell membranes immobilized on the electrode on the bottom of each assay plate. Upon application of an electric current, the receptor-bound Ru(bpy)2+3-ligand undergoes an oxidation-reduction cycle in the presence of a coreactant tripropylamine and emits light. Signal is only generated when the Ru(bpy)2+3 label is in proximity to the electrode, thus discriminating the bound label from the unbound and enabling a no wash, homogenous assay format. The ECL-based NMUR2 binding assay is used to screen our corporate compound collection. Approximately 670,000 compounds with diverse structures are tested at 10 μM for their ability to displace the binding of 0.5 nM Ru(bpy)2+3-NMU-23 to human NMUR2 receptors. From competition binding experiments, the Ki values for NMU-23 is determined to be 4.7 nM[1].

References:
[1]. Liu JJ, et al. Discovery and pharmacological characterization of a small-molecule antagonist at neuromedin U receptor NMUR2. J Pharmacol Exp Ther. 2009 Jul;330(1):268-75.