CAS NO: | 64439-81-2 |
包装 | 价格(元) |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | (±)-10-Hydroxycamptothecin is an indole alkaloid that inhibits the activity oftopoisomeraseIand has a broad spectrum of anticancer activity. | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | (±)-10-Hydroxycamptothecin (10-OH-camptothecin) is an inhibitor of topo I[1]. (±)-10-Hydroxycamptothecin (10-HCPT, 5-20 nM) markedly inhibits the proliferation of Colo 205 cells in a dose-dependent manner. (±)-10-Hydroxycamptothecin (5-20 nM) arrests Colo 205 cells in the G2 phase of the cell cycle and triggers apoptosis through a caspase-3-dependent pathway[2]. (±)-10-Hydroxycamptothecin (HPT, 0.01-10 μg/mL) causes cell shrinage, nuclear fragmentation and condensed chromosomes and induces apoptosis of human urinary bladder cancer cell line (T24)[3]. | ||||||||||||||||
体内研究 (In Vivo) | (±)-10-Hydroxycamptothecin (10-HCPT, 2.5-7.5 mg/kg/2 days, p.o.) significantly suppresss tumor growth in mouse xenografts. (±)-10-Hydroxycamptothecin (1-7.5 mg/kg, p.o., once per 2 or 4 days) causes no obvious acute toxicity in nude mice[2]. | ||||||||||||||||
分子量 | 364.35 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C20H16N2O5 | ||||||||||||||||
CAS 号 | 64439-81-2 | ||||||||||||||||
中文名称 | (±)-10-羟基喜树碱 | ||||||||||||||||
结构分类 |
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来源 |
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运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 25 mg/mL(68.62 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
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