您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > Bisantrene
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Bisantrene
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Bisantrene图片
CAS NO:78186-34-2
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议
200mg电议

产品名称
比生群
CL216942
产品介绍
Bisantrene 是高效的抗癌剂,它通过影响 DNA 插入发挥细胞毒性。Bisantrene 靶向真核生物的拓扑异构酶 II。Bisantrene 是 MDR1 的底物。
生物活性

Bisantrene is a highly effective antitumor agent, it exerts its cytotoxicity by affecting DNA intercalation. Bisantrene targets eukaryotic typeII topoisomerases. Bisantrene is a substrate of MDR1[1][2][3][4].

IC50& Target[1]

Topoisomerase II

 

体外研究
(In Vitro)

Bisantrene promots DNase I cleavage at oligopurine-oligopyrimidine tracts and slightly reduces the cleavage activity at alternating purine-pyrimidine sequences[1].
Bisantrene is an inhibitor of [3H]uridine incorporation into RNA and [3H]thymidine incorporation into DNA[2].

体内研究
(In Vivo)

Bisantrene is an antitumor agent active against a number of experimental tumors, including P388 leukemia, L1210 leukemia, Lieberman plasma cell tumor, B16 melanoma, colon tumor 26, and Ridgway osteogenic sarcoma[3].
Bisantrene is effective over a dose range of 1.56 to 150 mg/kg depending upon the frequency, route, and schedule of the treatment and the tumor model used[3].
Bisantrene (25, 50 and 100 mg/kg; i.p.; once) pretreats with macrophages shows antitumor effect to mice with P815 tumor cells injection[3].
Bisantrene (10-150 mg/kg; i.v.; once) dose-dependently induces leukopenia in Neo mice. B cells and macrophages are targets for bisantrene toxicity[4].

Clinical Trial
分子量

398.46

性状

Solid

Formula

C22H22N8

CAS 号

78186-34-2

中文名称

比生群;必桑郡

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

DMSO : 1 mg/mL(2.51 mM;ultrasonic and warming and heat to 80℃)

H2O : 0.1 mg/mL(0.25 mM;ultrasonic and warming and heat to 50℃)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM2.5097 mL12.5483 mL25.0966 mL
5 mM---------
10 mM---------
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。