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KD-3010
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
KD-3010图片
CAS NO:934760-92-6
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
KD-3010 是一种具有口服活性的有效的选择性PPARδ激动剂。
生物活性

KD-3010 is a potent, orally active, and selectivePPARδagonist.

IC50& Target[1]

PPARδ

 

体内研究
(In Vivo)

To determine whether PPARδ agonists are beneficial in experimental liver fibrosis, mice are treated orally with a PPARδ agonist, KD-3010, or with the well-validated PPARδ agonist GW501516. KD-3010, but not GW501516, shows hepatoprotective and antifibrotic effects in liver fibrosis induced by carbon tetrachloride (CCl4) or bile duct ligation (BDL). Liver injury is induced by repeated injections of CCl4, and mice are treated daily with vehicle, the widely used PPARδ agonist GW501516, or the PPARδ agonist KD-3010 by oral gavage. Control oil-injected mice do not show any liver damage. Liver injury consisting of hepatocyte death and inflammation is seen in the vehicle- or GW501516-treated group injected with CCl4on H&E-stained liver sections but is markedly reduced in the KD3010-treated group[1].

分子量

670.72

Formula

C30H33F3N2O8S2

CAS 号

934760-92-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.