ST247 a potentPPARβ/δinverse agonist. ST247 has a higher affinity toPPARβ/δ. ST247 modulates expression of the activation marker CCL2 in the opposite direction. ST247 efficiently induces the interaction with corepressors. ST247 inhibits the agonist-induced transcriptional activity ofPPARβ/δ^[1].

ST247 induces a clearly enhanced interaction of the PPARβ/δ LBD with the SMRT-ID2 peptide, with an EC₅₀of 10 nM^[1].
ST247 down-regulates basal level expression of the peroxisome proliferator responsive element-driven PPARβ/δ target gene ANGPTL4, with an IC₅₀of 19.1 nM^[1].

426.55

C₁₉H₂₆N₂O₅S₂

1356497-91-0

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.