Fmoc-leucine-d3 is the deuterium labeled Fmoc-leucine. Fmoc-leucine is a selectivePPARγ modulator. Fmoc-leucine activatesPPARγwith a lower potency but a similar maximal efficacy than rosiglitazone. Fmoc-leucine improvesinsulinsensitivity in normal, diet-induced glucose-intolerant, and in diabetic db/db mice. Fmoc-leucine has a lower adipogenic activity^[1].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

356.43

C₂₁H₂₀D₃NO₄

538372-74-6

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.