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(S)-Coriolic acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(S)-Coriolic acid图片
CAS NO:29623-28-7
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
13(S)-HODE
产品介绍
(S)-Coriolic acid (13(S)-HODE) ,亚油酸的15-脂氧合酶 (15-LOX) 代谢产物,作为内源性配体激活PPARγ。(S)-Coriolic acid 是一种重要的细胞内信号剂,在各种生物系统中参与细胞增殖和分化。(S)-Coriolic acid 诱导线粒体功能障碍 (mitochondrial dysfunction) 和气道上皮损伤。
生物活性

(S)-Coriolic acid (13(S)-HODE), the product of 15-lipoxygenase (15-LOX) metabolism of linoleic acid, functions as the endogenous ligand to activatePPARγ. (S)-Coriolic acid is an important intracellular signal agent and is involved in cell proliferation and differentiation in various biological systems. (S)-Coriolic acid inducesmitochondrial dysfunctionand airway epithelial injury[1][2][3].

体外研究
(In Vitro)

(S)-Coriolic acid (25μM) causes mitochondrial structural alterations and injury in bronchial epithelium[2].
(S)-Coriolic acid (30 nM; 6 hours; E-FABP-/-keratinocytes) induces K1 expression through NF-κB activation. (S)-Coriolic acid increases the phosphorylation of IκBαat serine 32, which induces IκB degradation and thereby activates NF-κB. (S)-Coriolic acid also increases the phosphorylation of Ikkinase-bat tyrosine 199, which promotes IκBα phosphorylation and subsequent NF-kB activation[3].

体内研究
(In Vivo)

(S)-Coriolic acid (0-0.6 mg per mouse; Intranasally once a day for 3 consecutive days) causes severe airway dysfunction, airway neutrophilia, mitochondrial dysfunction and epithelial injury[2].

Animal Model:BALB/c mice (6-8 weeks)[2]
Dosage:0-0.6 mg per mouse
Administration:Intranasally once a day for 3 consecutive days
Result:BALB/c mice developed features of mitochondrial dysfunction such as reduction in mitochondrial membrane potential, reduction in complex IV activity in lung mitochondria, and increase in the levels of cytochrome c in lung cytosol.
分子量

296.44

Formula

C18H32O3

CAS 号

29623-28-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.