CAS NO: | 146062-44-4 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
生物活性 | Leriglitazone (Hydroxypioglitazone), a metabolite of pioglitazone. Leriglitazone (Hydroxypioglitazone) PioOH is aPPARγagonist, stabilizes thePPARγactivation function-2 (AF-2) co-activator binding surface and enhances co-activator binding, affording slightly better transcriptional efficacy. Leriglitazone (Hydroxypioglitazone) binds to thePPARγC-terminal ligand-binding domain (LBD) with aKiof 1.2 μM,Leriglitazone induces transcriptional efficacy of thePPARγ(LBD) with anEC50of 680 nM[1]. | ||||||||||||
IC50& Target | Ki: 1.2 μM (PPARγ LBD); EC: 680 nM (PPARγ LBD) (Leriglitazone)[1] | ||||||||||||
分子量 | 372.44 | ||||||||||||
性状 | Solid | ||||||||||||
Formula | C19H20N2O4S | ||||||||||||
CAS 号 | 146062-44-4 | ||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||
储存方式 |
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