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Nimorazole
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Nimorazole图片
CAS NO:6506-37-2
包装:1mg
市场价:1166元

产品介绍
Nimorazole (K-1900) 是一种 2-硝基咪唑，是一种缺氧细胞辐射增敏剂。
Cas No.6506-37-2
别名尼莫拉唑; K-1900
化学名4-(2-(5-nitro-1H-imidazol-1-yl)ethyl)morpholine
Canonical SMILESO=N(C1=CN=CN1CCN2CCOCC2)=O
分子式C9H14N4O3
分子量226.23
溶解度DMF: 10mg/mL,DMF:PBS (pH 7.2) (1:3): 0.25mg/mL,DMSO: 10mg/mL,Ethanol: 2mg/mL
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Nimorazole (K-1900) is a nitroimidazole anti-infective.

Nimorazole significantly improves the effect of radiotherapeutic management of supraglottic and pharynx tumors and can be given without major side-effects [1, 2]. Nimorazole is the only such agent to have shown a significant effect in a randomized controlled trial in head and neck cancer [3].

References:
[1]. Overgaard, J., et al., A randomized double-blind phase III study of nimorazole as a hypoxic radiosensitizer of primary radiotherapy in supraglottic larynx and pharynx carcinoma. Results of the Danish Head and Neck Cancer Study (DAHANCA) Protocol 5-85. Radiother Oncol, 1998. 46(2): p. 135-46.
[2]. Roy, R.B., S.M. Laird, and L. Heasman, Treatment of trichomoniasis in the female. A comparison of metronidazole and nimorazole. Br J Vener Dis, 1975. 51(4): p. 281-4.
[3]. Henk, J.M., K. Bishop, and S.F. Shepherd, Treatment of head and neck cancer with CHART and nimorazole: phase II study. Radiother Oncol, 2003. 66(1): p. 65-70.