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Helioxanthin 8-1
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Helioxanthin 8-1图片
CAS NO:840529-13-7
包装与价格：
包装价格(元)
5mg电议
10mg电议

产品介绍
Helioxanthin 8-1 是 helioxanthin 的类似物，具有显着的体外抗 HBV/HCV/HSV-1/HIV 活性，EC50 为 >5/10/1.4/15 uM。
Cas No.840529-13-7
别名11-(1,3-苯并二氧杂环戊烯-5-基)-8,9-二氢-1,3-苯并二氧杂环戊烯并[4,5-G]酞嗪-7,10-二酮,Helioxanthin analogue 8-1
化学名11-(benzo[d][1,3]dioxol-5-yl)-[1,3]dioxolo[4',5':3,4]benzo[1,2-g]phthalazine-7,10-diol
Canonical SMILESOC1=NN=C(O)C2=C1C=C3C=CC(OCO4)=C4C3=C2C5=CC6=C(OCO6)C=C5
分子式C20H12N2O6
分子量376.32
溶解度Soluble in DMSO
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Helioxanthin 8-1, an analogue of helioxanthin (ACH126447), is an inhibitor of HBV and HIV virus with EC50 values of 0.03 μM and 2.7 μM, respectively [1].

Helioxanthin 8-1 is the cyclic hydrazide derivative of helioxanthin and has shown significant in vitro antivirus activity with EC50 values of 0.03 μM and 2.7 μM for HBV and HIV, respectively [1]. In the ds-tet5 cells, helioxanthin 8-1 can inhibit duck hepatitis B virus (DHBV) DNA synthesis with a mean IC50 value of 0.25±0.05 μM. Besides, in induced cells and non-induced ds-tet5 cells, helioxanthin 8-1 has cytotoxic effect with CC50 values of 18±2 μM and 45±3 μM, respectively, by using an MTT assay [2].

References:
[1] Yeo H1, Li Y, Fu L, Zhu JL, Gullen EA, Dutschman GE, Lee Y, Chung R, Huang ES, Austin DJ, Cheng YC. Synthesis and antiviral activity of helioxanthin analogues. J Med Chem. 2005 Jan 27;48(2):534-46.
[2] Ying C1, Tan S, Cheng YC.  Helioxanthin analogue 8-1 inhibits duck hepatitis B virus replication in cell culture. Antivir Chem Chemother. 2010;21(2):97-103.