CAS NO: | 134-58-7 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | 8-Azaguanine is a purine analogue that shows antineoplastic activity. 8-Azaguanine functions as an antimetabolite and easily incorporates into ribonucleic acids, interfering with normal biosynthetic pathways, thus inhibiting cellular growth[1]. | ||||||||||||||||
IC50& Target |
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体外研究 (In Vitro) | 8-Azaguanine induces a decrease in cell viability in a dose, time and cell type dependent manner with MOLT3 cells being the most sensitive to 8-Azaguanine citotoxic effects (24h IC50: 10 μM) when compared with CEM cells (24h IC50: 100 μM). MOLT3 cell treated with 8-Azaguanine shows an increase in CD26 expression (MIF) compared with that of CEM cell submitted to the same conditions (65.4 versus 18.7)[1]. | ||||||||||||||||
分子量 | 152.11 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C4H4N6O | ||||||||||||||||
CAS 号 | 134-58-7 | ||||||||||||||||
结构分类 |
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运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 2 mg/mL(13.15 mM;ultrasonic and warming and adjust pH to 5 with HCl and heat to 60℃) 配制储备液
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以下溶剂前显示的百
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