Imipramine-d4 hydrochloride is the deuterium labeled Imipramine hydrochloride. Imipramine hydrochloride is an orally active tertiary amine tricyclic antidepressant. Imipramine hydrochloride is aFascin1inhibitor with antitumor activities. Imipramine hydrochloride also inhibitsserotonin transporterwith anIC₅₀value of 32 nM. Imipramine hydrochloride stimulates U-87MG glioma cellsautophagyand induces HL-60 cellapoptosis. Imipramine hydrochloride shows neuroprotective and immunomodulatory effects^{[1][2][3][4][5][6]}.

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

320.89

Solid

C₁₉H₂₁D₄ClN₂

61361-33-9

盐酸丙咪嗪 d4 (盐酸盐)

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)