CAS NO: | 97938-30-2 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
20mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | Sophoraflavanone G (Kushenol F) is iaolated fromSophora flavescensand shows anti-tumor and anti-inflammatory properties. Sophoraflavanone G (Kushenol F) induces MDA-MB-231 and HL-60 cellsapoptosisthrough suppression of MAPK-related pathways[1][2]. | ||||||||||||||||
IC50& Target | IC50: 29.7 μM (MDA-MB-231 cell)[1] | ||||||||||||||||
体外研究 (In Vitro) | Sophoraflavanone G (0 -100 μM; 24 hours) decreases the viability of the HL-60 cells in a dose-dependent manner[1].Sophoraflavanone G (0 -100 μM; 24 hours) induces HL-60 cell apoptosis, activated caspase-3 and caspase-9, and downregulated Bcl-2 and Bcl-xL. It also upregulates Bax and released cytochrome c from the mitochondria into the cytoplasm, enabling apoptosis via the mitochondrially-mediated "intrinsic" pathway[1]Sophoraflavanone G (0 -40 μM; 24 hours) inhibits MDA-MB-231 cell viability in a concentration-dependent manner, with an IC50value of 29.7 ± 5.2 μM[2]<.br> | ||||||||||||||||
分子量 | 424.49 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C25H28O6 | ||||||||||||||||
CAS 号 | 97938-30-2 | ||||||||||||||||
中文名称 | 苦参总黄酮; 苦参酚 F | ||||||||||||||||
结构分类 |
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来源 |
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运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 250 mg/mL(588.94 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
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