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Fascaplysin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Fascaplysin图片
CAS NO:114719-57-2
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Fascaplysin 是一种抗微生物和细胞毒性的红色素,可来自海洋海绵Fascaplysinopsissp.。Fascaplysin 是以吲哚为原料,经7步合成的(得率 65%)。Fascaplysin 可诱导人白血病 HL-60 细胞凋亡和自噬。Fascaplysin 具有抗肿瘤活性。
生物活性

Fascaplysin is an antimicrobial and cytotoxic red pigment, that can come from the marinesponge(Fascaplysinopsissp.). Fascaplysin has been synthesized in seven steps from indole (65% yield). Fascaplysin can inducesapoptosisandautophagyin human leukemia HL-60 cells. Fascaplysin shows anti-tumor activity[1][2].

体外研究
(In Vitro)

Fascaplysin induces autophagy as a cytoprotective response via ROS and p8 in vascular endothelial cells (VECs)[2].
Fascaplysin targets metabolic activity of the prostate cancer cells, without disrupting cell membrane's integrity[2].
. Fascaplysin induces caspase mediated crosstalk between apoptosis and autophagy through the inhibition of PI3K/AKT/mTOR signaling cascade in human leukemia HL-60 cells[2].

体内研究
(In Vivo)

Fascaplysin suppresses the growth of S180 cell-implanted tumorsin vivo[2]

分子量

306.75

Formula

C18H11ClN2O

CAS 号

114719-57-2

结构分类
  • Alkaloids
  • Indole Alkaloids
来源

sponge

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.