CAS NO: | 54447-84-6 |
包装 | 价格(元) |
500 μg | 电议 |
1mg | 电议 |
Cas No. | 54447-84-6 |
别名 | 环二腺苷酸; Cyclic diadenylate; Cyclic-di-AMP |
化学名 | (2R,3S,3aS,7aS,9R,10aS,14aS)-2,9-bis(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxydecahydrodifuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine 5,12-dioxide |
Canonical SMILES | NC1=C2C(N([C@@H]3O[C@@]([H])(COP4(O)=O)[C@@]([H])(OP(OC[C@@]5([H])[C@]([H])([C@H](O)[C@H](N6C7=NC=NC(N)=C7N=C6)O5)O4)(O)=O)C3O)C=N2)=NC=N1 |
分子式 | C20H24N10O12P2 |
分子量 | 658.41 |
溶解度 | Soluble in DMSO |
储存条件 | Store at -20℃, protect from light, stored under nitrogen |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | c-di-AMP (Cyclic diadenylate) is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP (Cyclic diadenylate) is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP (Cyclic diadenylate) acts as a potent mucosal adjuvant stimulating both humoral and cellular responses[1][2][3][4]. c-di-AMP (Cyclic diadenylate) signaling is a central factor in many Gram-positive bacteria regulating cell wall synthesis, potassium ion channels, DNA repair, and biofilm formation. c-di-AMP is also essential for cell growth, survival, and virulence of several well-known human pathogenic bacteria including S. aureus, L. monocytogenes, S. pyogenes, and Mycobacterium spp[1].c-di-AMP (Cyclic diadenylate) combines with model antigens, such as OVA or β-Gal, acts as a potent mucosal adjuvant stimulating both humoral and cellular responses[4]. References: |