RB-3

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RB-3

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:	2396639-11-3
包装:	5mg
市场价:	9500元

产品介绍

RB-3 是PRC1的抑制剂，结合到RING1B-BMI1f，其K_d值为2.8 μM。

生物活性

RB-3, aPRC1inhibitor, binds toRING1B-BMI1f, with aK_dof 2.8 μM^[1].

IC₅₀& Target

Kd: 2.8 μM (RING1B-BMI1f)^[1].

体外研究
(In Vitro)

RB-3 decreases the global level of H2A ubiquitination and induces differentiation in leukemia cell lines and primary acute myeloid leukemia (AML) samples^[1].
RB-3 inhibits H2A ubiquitination with an IC₅₀of 1.6 μM^[1].
RB-3 inhibits PRC1 and disrupts the interaction with nucleosomes^[1].
RB-3 reduces colony formation in a mixed lineage leukemia (MLL)-eleven nineteen leukemia (ENL) model^[1].

Western Blot Analysis^[1]

Cell Line:	TEX cells.
Concentration:	6, 12, 25 μM.
Incubation Time:	8d.
Result:	Dose-dependently increased C/EBPα-p42 protein levels.

分子量

417.89

Formula

C₂₄H₂₀ClN₃O₂

CAS 号

2396639-11-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.