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FLT3-IN-17
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
FLT3-IN-17图片
CAS NO:2758999-62-9
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
FLT3-IN-17 抑制CYPsFLT3突变体的活性 (IC50s:<0.5 nM for D835Y)。FLT3-IN-17 也是一种FAK抑制剂,IC50值为 12 nM。FLT3-IN-17 可用于癌症研究。
生物活性

FLT3-IN-17 inhibitsCYPsandFLT3mutants activity (IC50s:<0.5 nM for D835Y). FLT3-IN-17 is also aFAKinhibitor, with anIC50value of 12 nM.FLT3ligand-2 can be used in the research of cancers[1].

IC50& Target

IC50: 12 nM (FAK),<0.5 nM (D835Y)[2].

体外研究
(In Vitro)

FLT3-IN-17 (compound 25, 72 h) inhibits cell growth in HCT-116, MDA-MB-231, A375 cells[1].
FLT3-IN-17 (10 μM) inhibits cytochrome P450s (CYPs) with inhibition rates >55%[1].
FLT3-IN-17 inhibits FLT3 mutants activity (IC50s:<0.5 nM for D835Y, 1.6-183 nM for Ba/F3)[1].

Cell Proliferation Assay[1]

Cell Line:HCT-116, MDA-MB-231, A375 cells
Concentration:0-1 μM approximately
Incubation Time:72 h
Result:Inhibited cell growth with IC50values of 0.25, 0.46, 0.49 μM respectively.
分子量

480.61

Formula

C23H24N6O2S2

CAS 号

2758999-62-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.