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XY153
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
XY153图片
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
XY153 (compound 8l) 是 BD2 选择性的BET抑制剂,选择性地与 BRD4 BD2 结合。XY153 与 BRD4 BD2,BRD3 BD2 和 BRD2 BD2 结合IC50值分别为 0.79,5.31 和 5.09 nM。XY153 对多种肿瘤细胞系显示出有效的抗增殖活性。XY153 可用于急性髓性白血病和癌症的研究。
生物活性

XY153 (compound 8l) is a BD2-selectiveBETinhibitor and selectively binds toBRD4BD2. XY153 binds toBRD4BD2,BRD3BD2 andBRD2BD2 withIC50s of 0.79, 5.31 and 5.09 nM, respectively. XY153 shows potent antiproliferative activity against multiple tumor cell lines. XY153 can be used for the research of acute myeloid leukemia (AML) andcancer[1].

IC50& Target

IC50: 0.79 nM (BRD4 BD2), 5.31 nM (BRD3 BD2), 5.09 nM (BRD2 BD2)[1]

体外研究
(In Vitro)

XY153 shows strong antiproliferative activities for specific cancer cell lines but with a better safety profile against a normal lung fibroblast cell line[1].

Cell Viability Assay[1]

Cell Line:MV4-11, MOLM-13, Kasumi-1, THP-1, HT-29, 22Rv1, Du145, MCF-7, MDA-MB-231, A549, U2OS, U937, HepG2, BxPC-3 and HFL-1 cell lines
Concentration:0.001 nM-10 μM
Incubation Time:96 hours
Result:Inhibited acute myeloid leukemia (AML) cell lines with IC50s of 0.55 nM, 260 nM, 471 nM and 1.3 μM for MV4-11, MOLM-13, Kasumi-1 and THP-1 cell lines, respectively. Showed potent cytotoxicity to AR-positive prostate cancer cell line 22Rv1 and colorectal cancer cell line HT-29 with IC50s of 232 and 300 nM, respectively. Exhibited weak cytotoxicity to normal lung fibroblast cell line HFL-1 with an IC50value of 4.6 μM.
分子量

555.64

Formula

C33H34FN3O4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.