Pomalidomide-C5-Dovitinib (compound 2) is aPROTACcontaining Pomalidomide, Dovitinib and connected with CRBN. Pomalidomide-C5-Dovitinib shows enhanced antiproliferative effects against FLT3-ITD+ AML cells. Pomalidomide-C5-Dovitinib induces the degradation of the FLT3-ITD and KIT proteins in a ubiquitin-proteasome-dependent manner and completely blocks their downstream signaling pathway. Pomalidomide-C5-Dovitinib has the potential for the research of FLT3-ITD⁺acute myeloid leukemia^[1].

747.77

C₃₉H₃₈FN₉O₆

2732969-67-2

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