CAS NO: | 2170347-90-5 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | LSD1-IN-13 hydrochloride (compound 7e) is an orally active and potentLSD1inhibitor, with anIC50of 24.43 nM. LSD1-IN-13 hydrochloride can activate CD86 expression, with anEC50of 470 nM. LSD1-IN-13 hydrochloride induces differentiation of AML (acute myeloid leukemia) cell lines[1]. |
IC50& Target | IC50: 24.43 ± 1.08 nM (LSD1), 5.00 ± 0.28 μM (LSD2), >100 μM (MAO-A), >100 μM (MAO-B)[1] |
体外研究 (In Vitro) | LSD1-IN-13 hydrochloride (compound 7e) shows good selectivity over LSD2 (205-fold) and MAOs (>4000-fold)[1]. |
体内研究 (In Vivo) | LSD1-IN-13 hydrochloride (compound 7e) (MV-4-11 xenograft mice, 0-20 mg/kg, Orally, daily for 15 days) suppresses tumor growth significantly in a dose-dependent manner[1]. |
分子量 | 448.02 |
Formula | C23H30ClN3O2S |
CAS 号 | 2170347-90-5 |
运输条件 | Room temperature in continental US; may vary elsewhere. |
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |