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hDHODH-IN-11
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
hDHODH-IN-11图片
CAS NO:2396653-34-0
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
hDHODH-IN-11 是一种有效的人二氢旋转酸脱氢酶 (hDHODH) 抑制剂,其IC50值为 7.2 nM。hDHODH-IN-11具有低细胞毒性。hDHODH-IN-11 可用于急性髓系白血病 (AML) 的研究。
生物活性

hDHODH-IN-11 is a potent humandihydroorotate dehydrogenase(hDHODH)inhibitor with anIC50value of 7.2 nM. hDHODH-IN-11 has low cytotoxicity. hDHODH-IN-11 can be used in research of acute myeloid leukemia (AML)[1].

IC50& Target

IC50: 7.2 nM (hDHODH)[1]

体外研究
(In Vitro)

hDHODH-IN-11 (0.1 and 1 μM; 72 h; THP1 and U937 cells) has low cytotoxicity, pro-apoptotic and pro-differentiating abilities[1].
hDHODH-IN-11 (0.1 μM; 72 h; THP1 and MV4-11 cells) withDipyridamole(HY-B0312) results in synergistic effect and demonstrates a good pro-apoptotic activity[1].

体内研究
(In Vivo)

hDHODH-IN-11 (20 mg/kg; i.p.; daily, for 13 d; Balb/c mice with AML xenografts) reduces the leukemic burden and tumor weight[1].

Animal Model:Balb/c mice with AML xenografts[1]
Dosage:20 mg/kg
Administration:Intraperitoneal injection; daily, for 13 days
Result:Reduced the leukemic burden and tumor weight.
分子量

401.46

Formula

C24H23N3O3

CAS 号

2396653-34-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.