CAS NO: | 2396653-34-0 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | hDHODH-IN-11 is a potent humandihydroorotate dehydrogenase(hDHODH)inhibitor with anIC50value of 7.2 nM. hDHODH-IN-11 has low cytotoxicity. hDHODH-IN-11 can be used in research of acute myeloid leukemia (AML)[1]. | ||||||||
IC50& Target | IC50: 7.2 nM (hDHODH)[1] | ||||||||
体外研究 (In Vitro) | hDHODH-IN-11 (0.1 and 1 μM; 72 h; THP1 and U937 cells) has low cytotoxicity, pro-apoptotic and pro-differentiating abilities[1]. | ||||||||
体内研究 (In Vivo) | hDHODH-IN-11 (20 mg/kg; i.p.; daily, for 13 d; Balb/c mice with AML xenografts) reduces the leukemic burden and tumor weight[1].
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分子量 | 401.46 | ||||||||
Formula | C24H23N3O3 | ||||||||
CAS 号 | 2396653-34-0 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |