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QA-68
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
QA-68图片
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
QA-68-ZU81
产品介绍
QA-68 (QA-68-ZU81) 是一种有效的BRD9降解剂。QA-68 能抑制细胞周期进程和细胞集落形成。QA-68 对急性髓系白血病 (AML) 细胞系具有抗增殖活性。
生物活性

QA-68 (QA-68-ZU81) is a potentbromodomain-containing protein 9 (BRD9)degrader. QA-68 can inhibit cell cycle progression and cell colony formation. QA-68 has antiproliferative activity against acute myeloid leukemia (AML) cell lines[1].

IC50& Target[1]

BRD9

 

体外研究
(In Vitro)

QA-68 (0-1000 nM; 24 h) exhibits antiproliferative activity against MV4-11, SKM-1 and Kasumi-1-luc+ cells, and inhibits BRD9 protein expression in MV4-11, SKM-1, SEM, NALM6, RS4;11[1].
QA-68 (0.1-1000 nM; 4 days) effectively inhibits SKM-1 cell cycle progression[1].
QA-68 (1000 nM; 12 days) inhibits colony formation of additional primary AML bone marrow and PBMC cells[1].

Cell Proliferation Assay[1]

Cell Line:MV4-11, SKM-1 and Kasumi-1-luc+ cells
Concentration:0-1000 nM
Incubation Time:24 h
Result:Exhibited concentration-dependent inhibition of proliferation of MV4-11, SKM-1 and Kasumi-1-luc+ cells with IC50s of 1-10 nM in MV4;11 and SKM-1, and IC50 of 10-100 nM in Kasumi-1-luc +, respectively.

Cell Cycle Analysis[1]

Cell Line:SKM-1cells
Concentration:0.1, 1, 10, 100 and 1000 nM
Incubation Time:6 days
Result:Effectively inhibited SKM-1 cell cycle progression.

Western Blot Analysis[1]

Cell Line:MV4-11, SKM-1, SEM, NALM6, RS4;11
Concentration:0, 1, 10, 100 and 1000 nM
Incubation Time:24 h
Result:Inhibited BRD9 protein in all tested cell lines.
分子量

1169.42

Formula

C61H72N10O10S2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.