CAS NO: | 945260-14-0 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | (S)-3-Hydroxy Midostaurin ((S)-CGP52421) is a potent kinases inhibitor withIC50values of<400 nm for 13 kinases (vegfr-2, trk-a,FLT3, et). (S)-3-Hydroxy Midostaurin is a minor metabolite of midostaurin (PKC412; HY-10230) undergoing by the hepatic CYP3A4 enzyme. (S)-3-Hydroxy Midostaurin has the potential for acute myeloid leukemia (AML)[1]. |
体外研究 (In Vitro) | (S)-3-Hydroxy Midostaurin ((S)-CGP52421; compound 4) has IC50values in the range of 200-400 nM against the ITD and D835Y mutants and low micromolar activity against the wild-type enzyme[1]. |
分子量 | 586.64 |
Formula | C35H30N4O5 |
CAS 号 | 945260-14-0 |
运输条件 | Room temperature in continental US; may vary elsewhere. |
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |