CAS NO: | 2119595-80-9 |
包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
生物活性 | Teclistamab is a human bispecific antibody toBCMAandCD3that recognizes BCMA on target cells and CD3 on T cells and induces T cell-mediated cytotoxicity leading to T cell activation and subsequent targetcell lysis. Teclistamab can be used in studies of diseases related to multiple myeloma (MM)[1]. | ||||||||
体外研究 (In Vitro) | Teclistamab (0.01-1000 nM, 48 h) 可以诱导 T 细胞介导的细胞毒性,在 H929 细胞中的 EC50值为 0.15 nM,在MM.1R 细胞系中为 0.06 nM,在 RPMI 8226 细胞系中为 0.45 nM[1]。 | ||||||||
体内研究 (In Vivo) | Teclistamab (i.v., 0.1-1 μg, once every 2 days) 在雌性 NSG(NOD/SCID/γc-/)小鼠 H929 细胞模型中具有大剂量的抗肿瘤活性[1]。
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CAS 号 | 2119595-80-9 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |