CAS NO: | 2148354-90-7 |
包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
生物活性 | Tidutamab (XmAb-18087) is a humanized and affinity-optimized bispecific antibody (bsAb) targetingSSTR2binding domain andT-cell binding domain (CD3). Tidutamab possesses a full Fc domain to maintain long serum half-life.Tidutamab eliminates SSTR+ tumor cells by stimulating redirected T cellmediated cytotoxicity (RTcC)[1]. | ||||||||
体外研究 (In Vitro) | Tidutamab (XmAb-18087; 0-100000 ng/mL)与人 SSTR2+ CHO 细胞结合,ED50值为 2.2 μg/mL,并介导 T 细胞杀伤 SSTR2+ 靶细胞[1]。 | ||||||||
体内研究 (In Vivo) | Tidutamab (XmAb-18087; 3 mg/kg; i.p.; 单次注射) 在 NSG 小鼠中刺激人 T 细胞杀伤 SSTR2+ A549 肺癌肿瘤[1]。
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CAS 号 | 2148354-90-7 | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |