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Zanolimumab
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:652153-01-0
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品名称
Anti-Human CD4 Recombinant Antibody
产品介绍
Zanolimumab (Anti-Human CD4 Recombinant Antibody) 是一种人单克隆抗体,靶向CD4。Zanolimumab 可有效抑制 T 细胞受体 (TCR) 的信号转导。Zanolimumab 可用于类风湿性关节炎、银屑病、黑色素瘤、皮肤和周围 T 细胞淋巴瘤的研究。
生物活性

Zanolimumab (Anti-HumanCD4Recombinant Antibody) is a fully human monoclonal antibody targetsCD4. Zanolimumab effectively inhibits T-cell receptor (TCR) signal transduction. Zanolimumab can be used for the research of heumatoid arthritis, psoriasis, melanoma, cutaneous and peripheral T-cell lymphoma[1].

体外研究
(In Vitro)

Zanolimumab (10 and 100 ng/mL) shows strong killing of the CD4+T cells with a better effect to CD45RO+subset than the CD45RA+subset[1].
Zanolimumab (1-10000 ng/mL) Fc and dose-dependently down-regulates the level of CD4 from purified primary CD4+T cells and SUP-T1 T cells[1].
Zanolimumab (1-10000 ng/mL) potently inhibits of TCR-stimulated T-cell proliferation both in tetanus toxin induced and anti-CD3 induced T-cell proliferation[1].
Zanolimumab (0-30 min) inhibits TCR signal transduction[1].

分子量

147 (kDa)

CAS 号

652153-01-0

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.