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LSD1/2-IN-3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
LSD1/2-IN-3图片
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
LSD1/2-IN-3 是赖氨酸特异性去甲基化酶 1 (LSD1) 的选择性抑制剂,Ki为 11 nM,而对LSD2的 Ki值为 7 μM。LSD1在癌干细胞中异常表达,LSD1/2-IN-3 能够抑制LSD1活性和癌细胞增殖。
生物活性

LSD1/2-IN-3 is a selective inhibitor oflysine-specific demethylase 1(LSD1), with aKivalue of 11 nM instead of 7 μM forLSD2. There is aberrant expression ofLSD1incancer stem cells, LSD1/2-IN-1 inhibitsLSD1cell proliferation[1].

IC50& Target

Ki: 11 nM (LSD1); 7 μM (LSD2)[1]

体外研究
(In Vitro)

LSD1/2-IN-3 (compound 8c) inhibits proliferation of the T-cell acute lymphoblastic leukemia (T-ALL) with IC50s of 25 μM (CCRF-CEM) and 27 μM (Jurkat), respectively, without inhibiting the human normal fibroblast cell line WI-38[1].

分子量

248.07

Formula

C9H8BrF2N

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.