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PD-1/PD-L1-IN-25
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PD-1/PD-L1-IN-25图片
CAS NO:2768759-52-8
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
PD-1/PD-L1-IN-25 (compound D2) 是PD-1/PD-L1互作的抑制剂,IC50值为 16.17 nM。PD-1/PD-L1-IN-25 能够激活 PBMCs 中 T 细胞的抗肿瘤免疫。PD-1/PD-L1-IN-25 可用于癌症的研究。
生物活性

PD-1/PD-L1-IN-25 (compound D2) is an inhibitor ofPD-1/PD-L1interaction with anIC50value of 16.17 nM. PD-1/PD-L1-IN-25 activates the antitumor immunity of T cells efficiently in PBMCs. PD-1/PD-L1-IN-25 can be used for the research ofcancer[1].

IC50& Target

IC50: 16.17 nM (PD-1/PD-L1)[1].

体外研究
(In Vitro)

PD-1/PD-L1-IN-25 (0-1 μM; 90 min) inhibits PD-1/PD-L1 interaction with anIC50value of 16.17 nM[1].
PD-1/PD-L1-IN-25 (0-2 μM; 2 h) activates the antitumor immunity of T cells efficiently in PBMCs[1].

Cell Cytotoxicity Assay[1]

Cell Line:MDA-MB 231 cells by human PBMCs
Concentration:0-2 μM
Incubation Time:2 hours
Result:Showed no toxicity towards MDA-MB 231 cells, and activated the antitumor immunity of PBMCs to kill MDA-MB 231 cells efficiently at a concentration of 1.0 μM.
分子量

493.94

Formula

C26H24ClN3O5

CAS 号

2768759-52-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.