4-Hydroperoxy Cyclophosphamide-d4 is the deuterium labeled 4-Hydroperoxy cyclophosphamide. 4-Hydroperoxy cyclophosphamide is the active metabolite form of the prodrug Cyclophosphamide. 4-Hydroperoxy cyclophosphamide crosslinksDNAand induces T cellapoptosisindependent ofdeath receptoractivation, but activates mitochondrial death pathways through production ofreactive oxygen species(ROS). 4-Hydroperoxy cyclophosphamide has the potential for lymphomas and autoimmune disorders^[1][2].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

297.11

Solid

C₇H₁₁D₄Cl₂N₂O₄P

1246816-71-6

Room temperature in continental US; may vary elsewhere.

-80°C, stored under nitrogen